TITLE:
Effect of Post-ERCP Pancreatitis on Perioperative Factors of Pancreaticoduodenectomy
AUTHORS:
Teijiro Hirashita, Toshifumi Matsumoto, Koichi Izumi, Masahiko Ikebe, Tokujiro Yano, Yoichi Muto, Susumu Matsuo
KEYWORDS:
Endoscopic Retrograde Cholangiopancreatography, Post-ERCP Pancreatitis, Pancreaticoduodenectomy
JOURNAL NAME:
Surgical Science,
Vol.6 No.2,
February
9,
2015
ABSTRACT: Background:Endoscopic
retrograde cholangiopancreatography (ERCP) is commonly performed for biliary
drainage and examination of the biliary and pancreatic duct before
pancreaticoduodenectomy (PD). The influence of preoperative post-ERCP
pancreatitis on PD is unknown. The aim of this study was to evaluate the
relation between post-ERCP pancreatitis before PD and surgical outcomes of PD.
Methods: We examined 38 patients who underwent PD. The relations between
post-ERCP pancreatitis before PD and perioperative factors of PD such as
patient characteristics, operative findings, and postoperative course were
evaluated with univariate and multivariate analyses. Results: Post-ERCP
pancreatitis was observed in 12 (37.5%) of the 38 patients. Univariate analyses
showed operative procedure (P= 0.034), operation time (P= 0.004), blood loss (P= 0.031), C-reactive protein (P= 0.043), and delayed gastric emptying (P= 0.035) to be significantly associated with
post-ERCP pancreatitis. Multivariate analyses showed operation time (OR, 1.017;95%CI, 1.000 - 1.034;P= 0.049) and delayed gastric emptying (OR, 18.72;
95%CI, 1.139 - 307.6;P= 0.040) to be significantly associated with post-ERCP
pancreatitis. Conclusions: Post-ERCP pancreatitis was associated with prolonged
operation time and delayed gastric emptying in patients undergoing PD.