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Krishna, G., Xu, J., Nath, J., Petersen, M. and Ong, T. (1985) In Vivo Cytogenic Studies on Mice Exposed to Ethylene Dibromide. Mutation Research/Genetic Toxicology, 158, 81-87. http://dx.doi.org/10.1016/0165-1218(85)90101-6

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• TITLE: Genotoxic and Cytotoxic Damage by Cyclophosphamide and Adriamycin as a Response to Treatment in Breast Cancer Patients: Pilot Study

  AUTHORS: Jimena Garibay-Garcia, Fernando Mejia-Sanchez, Eduardo Ramírez-San-Juan, Miriam V. Flores-Merino, Julieta Castillo-Cadena

  KEYWORDS: Sister Chromatid Exchange, Genotoxicity Biomarkers, Breast Cancer, Cyclophosphamide, Adriamycin

  JOURNAL NAME: Journal of Cancer Therapy, Vol.6 No.2, February 5, 2015

  ABSTRACT: The aim of this study was to evaluate the genotoxicity induced by cyclophosphamide-adriamycin treatment in breast cancer patients through the frequencies of Sister Chromatid Exchange (SCE), Replication Index (RI), Mitotic Index (MI) and Cell Proliferation Index (CPI) and to study the possible association between biomarkers of genotoxicity and the early response to treatment. The frequencies were obtained before and immediately after therapy from 17 patients with breast cancer (p