TITLE:
Genotoxic and Cytotoxic Damage by Cyclophosphamide and Adriamycin as a Response to Treatment in Breast Cancer Patients: Pilot Study
AUTHORS:
Jimena Garibay-Garcia, Fernando Mejia-Sanchez, Eduardo Ramírez-San-Juan, Miriam V. Flores-Merino, Julieta Castillo-Cadena
KEYWORDS:
Sister Chromatid Exchange, Genotoxicity Biomarkers, Breast Cancer, Cyclophosphamide, Adriamycin
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.2,
February
5,
2015
ABSTRACT: The aim of this study was to evaluate
the genotoxicity induced by cyclophosphamide-adriamycin treatment in breast
cancer patients through the frequencies of Sister Chromatid Exchange (SCE),
Replication Index (RI), Mitotic Index (MI) and Cell Proliferation Index (CPI)
and to study the possible association between biomarkers of genotoxicity and
the early response to treatment. The frequencies were obtained before and
immediately after therapy from 17 patients with breast cancer (p