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Dacosta-Aguayo, R., Gra?a, M., Fernández-Andújar, M., López-Cancio, E., Cáceres, C., Bargalló, N., Barrios, M., Clemente, I., Monserrat, P.T., Sas, M.A., Dávalos, A., Auer, T. and Mataró, M. (2014) Structural Integrity of the Contralesional Hemisphere Predicts Cognitive Impairment in Ischemic Stroke at Three Months. PLoS ONE, 9, e86119. http://dx.doi.org/10.1371/journal.pone.0086119

has been cited by the following article:

• TITLE: White Matter Changes in Alzheimer’s Disease Revealed by Diffusion Tensor Imaging with TBSS

  AUTHORS: Hongyan Chen, Kai Wang, Jingfan Yao, Jianping Dai, Jun Ma, Shaowu Li, Lin Ai, Qian Chen, Xuzhu Chen, Yumei Zhang

  KEYWORDS: Alzheimer Disease, Diffusion Tensor Imaging, Fractional Anisotropy, TBSS

  JOURNAL NAME: World Journal of Neuroscience, Vol.5 No.1, February 5, 2015

  ABSTRACT: Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder characterized by impairments in multiple cognitive domains and it is hard to diagnose in early stage because it’s not easy to recognize and develop slowly. In this study, we try to evaluate the difference of white matter between AD and health volunteers using diffusion tensor imaging (DTI) and try to provide some evidence for diagnose AD in early stage. Twelve elderly Chinese patients with AD and twelve healthy volunteers were recruited and underwent DTI. The raw diffusion data were dealt with the toolkit of FSL image post-processing. Fractional anisotrogy (FA) data were then carried out by using tract-based spatial statistics (TBSS). The result showed that the FA of cingulum, hippocampus, corticospinal tract, and inferior fronto-occipital fasciculus significantly reduced in AD patients than that of volunteers. This indicated that the integrity of white matter tracts in these regions with AD was disturbed. On the other hand, the FA of other encephalic regions had no discrepancy compared with that of healthy volunteers. FA values were found reduced significantly in AD patients, especially in the posterior of the brain. These findings may provide image methods to diagnose patients with early stage of AD.