TITLE:
Nimotuzumab in Treatment of Infiltrating Squamous Cell Carcinoma of Tongue
AUTHORS:
Alex A. Prasad
KEYWORDS:
Nimotuzumab, Epidermal Growth Factor Receptor (EGFR), Transforming Growth Factor α (TGFα)
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.2,
January
30,
2015
ABSTRACT: A 50-year male patient presented to
outpatient department with a mass on tongue associated with pain. A plain
computerised tomography scan done on 17/01/13 revealed mild growth on lateral
border of tongue with an enlarged jugulo-digastric lymph node measuring 1.8×1
cm. Excision of tongue was done and sent for histopathological examination
which revealed infiltrating squamous cell carcinoma. The patient was treated
with 2 cycles of Induction chemotherapy with cisplatin and paclitaxel
administered in q3w schedule. Induction chemotherapy was followed by concurrent
chemoradiotherapy with 6 cycles of nimotuzumab 200 mg and cisplatin 20 mg given
weekly along with 60 gy/30 fractions of radiation using IMRT. Latest CT scan
done on 20/01/2014 revealed no evidence of disease (NED).