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J. Z. Xing, L. Zhu, S. Gabos, and L. Xie, “Microelec-tronic cell sensor assay for detection of cytotoxicity and prediction of acute toxicity,” Toxicology in Vitro, Vol. 20, pp. 995?1004, 2006.

has been cited by the following article:

• TITLE: Effects of Estrogen Contamination on Human Cells: Modeling and Prediction Based on Michaelis-Menten Kinetics

  AUTHORS: F. IBRAHIM, B. HUANG, J. Z. XING, W. ROA, Stephan GABOS

  KEYWORDS: Water Protection, Early Warning, Estrogen, Mathematical Modeling, Parameter Estimation, Prediction

  JOURNAL NAME: Journal of Water Resource and Protection, Vol.1 No.5, November 24, 2009

  ABSTRACT: In this paper, we propose a novel prevention strategy to alert citizens when water is contaminated by estro-gen. Epidemiological studies have shown that chronic exposure to high blood level of estrogen is associated with the development of breast cancer. The preventive strategy proposed in this paper is based on the predic-tion of estrogen effects on human living cells. Based on first principle insights, we develop in this work, a mathematical model for this prediction purpose. Dynamic measurements of cell proliferation response to es-trogen stimulation were continuously monitored by a real-time cell electronic sensor (RT-CES) and used in order to estimate the parameters of the model developed.