TITLE:
Esophageal Strictures during Treatment with a Proton Pump Inhibitor
AUTHORS:
Einar Arnbjörnsson, Torbjörn Backman
KEYWORDS:
Gastroesophageal Reflux (GER), Omeprazole, Esophagitis, Esophageal Stricture, Proton Pump Inhibitor (PPI), An Antineoplastic Treatment
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.5 No.1,
January
29,
2015
ABSTRACT: Background: The development of esophageal stricture during
treatment with high dose chemotherapeutic agents is well known and documented
in the literature. With the introduction of proton pumps inhibitors (PPI), the
gastroesophageal reflux disease (GERD) induced stricture has shown significant
improvement. The aim of this report is to remind of the fact that the
chemotherapy induced strictures show poor response and their treatment is still
a challenge. Case presentation: Here, we reported a boy with Down syndrome and
congenital heart disease who developed acute lymphoblastic leukemia and
subsequent esophageal stricture during treatment with a PPI. Conclusion: It is
important to be aware of this potential complication of gastroesophageal reflux
or antineoplastic treatment, even in cases thought to be adequately treated
with a proton pump inhibitor, and that the start of PPI’s is also the start of
an evaluation of the use of this medication.