TITLE:
The Effect of Soy Nuts on Glycemic Control, Lipid Profile and Insulin-Resistance in Type 2 Diabetic Patients
AUTHORS:
Alireza Sedaghat, Hajieh Shahbazian, Fatemeh Haidari, Seyed Peyman Payami, Alireza Jahanshahi, Seyed Mahmoud Latifi
KEYWORDS:
Type 2 Diabetes, Soy Nuts, Blood Glucose, Blood Pressure, Lipid Profile
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.5 No.1,
January
21,
2015
ABSTRACT: Type 2
diabetes has a high prevalence and a growing trend. The use of a proper diet
treatment is one of the therapeutic approaches of patients. The use of the soy has
shown the effective results in glycemic control of patients with type 2
diabetes; however, data are paradoxical. The present study aimed to examine the
effectiveness of soy nuts on glycemic control, blood pressure and lipid profile
and insulin-resistance of the diabetic patients. Methods: In this case-control study 69 type
2 diabetic patients were randomly divided into two groups: intervention (n =
35) and control (n = 34). The patients in the intervention group substituted 60
grams of soy nuts as a part of the daily protein requirement for eight weeks. In
contrast, the patients in the control group received usual diet of diabetes (no
soy). The drugs received by patients had not been
changed during the intervention period. Before and at the end of the
intervention, Hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), serum
insulin levels, insulin-resistance, systolic and diastolic blood pressure, low
density lipoprotein-cholesterol (LDL-c), high density lipoprotein-cholesterol
(HDL-c) and total cholesterol, and triglycerides (TG) were measured in the
patients. Insulin-resistance was calculated by Homeostatic model assessment-IR
formula (HOMA-IR). Results: Soy consumption significantly lowered
FPG (P = 0.03), HbA1c (P P = 0.01), insulin-resistance (P = 0.01), total cholesterol (P P = 0.01), but did not have any
significant effect on systolic blood pressure (P = 0.4), diastolic blood pressure (P = 0.2), HDL-c (P = 0.4)
and TG (P = 0.2). Conclusion: Consumption of soy nuts in type
2 diabetic patients can cause an improvement in the glycemic control and insulin-resistance,
and the lipid profile does not have any significant effect on blood pressure.