TITLE:
Amyloid Goiter: Clinicopathological Assessment of Two Cases and Review of Literature
AUTHORS:
Rabab Ahmed Ahmed Mohammed, Etemad Helmy Yassin, Moustafa EzEldien M. Radwan, Badawy Mohammed Ahmed, Lobna F. Ettouny, Alaa M. Abozied
KEYWORDS:
Amyloidosis, Amyloid Goiter, Thyroid Gland
JOURNAL NAME:
Open Journal of Pathology,
Vol.5 No.1,
January
16,
2015
ABSTRACT: Amyloid goiter (AG) is a rare but well-established disease entity that
may occur in a number of conditions. In the following article, we will report
two cases of AG. Both patients were young males: 28 & 24 years old, presented
with rapidly enlarging thyroid gland manifested with pressure effects (dyspnea
and hoarseness of voice). Provisional clinical diagnosis was malignant thyroid
neoplasm. One of the patients was markedly hypothyroid while the other was
euthyroid. Histopathological evaluation revealed extracellular deposition of
deep pink homogenous material that was confirmed as amyloid with congo red. Patient in case 1 was
primary localized AG while patient in case 2 was systemic amyloidosis secondary
to interstitial pulmonary fibrosis (IPF) that was first manifested by AG. The
main aims of the article were to describe histopathological features of
amyloidosis of the thyroid gland and to raise awareness of AG to be included in
the differential diagnosis in patients presented with rapidly enlarging goiter
with mass effects.