TITLE:
Staphylococcus haemolyticus superinfection of legionella pneumonia during infliximab therapy
AUTHORS:
Marianna Porzio, Luca Valenti, Daniela Bignamini, Francesca Ricchini, Alessandro Palleschi, Paolo Tarsia, Silvia Fargion
KEYWORDS:
Infliximab; Legionella Pneumophila; Linezolid; Necrotizing Pneumonia; Psoriasis; Staphylococcus Haemolyticus
JOURNAL NAME:
Open Journal of Internal Medicine,
Vol.1 No.1,
June
29,
2011
ABSTRACT: We present the case of a 42-year-old man affected by psoriasis with Staphylococcus Haemolyticus superin-fection of Legionella pneumonia during infliximab therapy. The introduction of compounds that block TNF-α has yielded great benefits for patients affected by selected autoimmune diseases that fail to respond to classic anti-inflammatory agents, but, on the other hand, has led to an increased susceptibility to infec-tions, in particular of those caused by intracellular pathogens, such as L. Pneumophila. Emerging evi-dence suggests that legionellosis can be complicated by superinfection with other agents, including sap-rophytic microorganisms, among which coagulase- negative staphylococci. To our knowledge, this is the first report of systemic legionellosis with superinfec-tion by S. Haemolyticus, an emerging nosocomial multi-resistant pathogen that commonly causes sep-ticemia, osteomyelitis or endocarditis, but has not so far been associated with necrotizing pneumonia. De-spite the optimal antimicrobial therapy for Staphylo-coccus spp. pneumonia is still controversial, evidence suggests that in patients with confirmed positivity for methicillin resistant strains, particularly if sensitivity to vancomycin is suboptimal, linezolid should be the first choice therapy, being superior to vancomycin and teicoplanin.