TITLE:
Primary Endometrial High Grade Neuroendocrine Carcinoma: A Case Report with Cytological, Histopathological and Immunohistochemical Features
AUTHORS:
Kazuhiro Kobayashi, Masashi Matsuyama, Fumimasa Etori, Naomi Kawaguchi, Kyoko Nambu, Asuka Sekiya, Yuka Hiraku, Kazushige Yamamoto, Naoki Watanabe, Tetsuya Yamada, Takuji Tanaka
KEYWORDS:
Endometrium, High Grade Neuroendocrine Carcinoma, Undifferentiated Carcinoma, Neuroendocrine Cells
JOURNAL NAME:
Open Journal of Pathology,
Vol.5 No.1,
January
9,
2015
ABSTRACT: An 84-year-old woman suffered from post-menopausal genital bleeding for 3 months. Based on the endometrial cytological findings (suggestive of high grade neuroendocrine carcinoma) showing that there were rosette-like and cord-like structures consisting of small rounded tumor cells with oval nuclei and scanty cytoplasm, radical hysterectomy was performed. Histopathological and immunohistochemical examinations on the operated specimens revealed primary high grade neuroendocrine carcinoma of the endometrium. Despite the extensive treatment against the malignancy, the patient died due to widespread metastases after 5 months after the surgery and autopsied.