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Wallace, D.G., Cruise, G.M., Rhee, W.M., Schroeder, J.A., Prior, J.J., Ju, J., Maroney, M., Duronio, J., Ngo, M.H., Estridge, T. and Coker, G.C. (2001) A Tissue Sealant Based on Reactive Multifunctional Polyethylene Glycol. Journal of Biomedical Materials Research (Applied Biomaterials), 58, 545-555. http://dx.doi.org/10.1002/jbm.1053

has been cited by the following article:

• TITLE: Polyamine-Polymeric Micelle Hybrid Hydrogel: Microscopic Properties of Crosslinkers Affecting Macroscopic Rheological Properties of Hydrogel

  AUTHORS: Chikara Yoshida, Tomoki Ito, Ryosuke Anzai, Kengo Fukuda, Keita Kinoshita, Seiichi Sonotaki, Taku Takami, Yoshihiko Murakami

  KEYWORDS: Hydrogel, Polymeric Micelle, Self-Assembly, Crosslinker, Block Copolymer

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.6 No.1, January 9, 2015

  ABSTRACT: We have developed a hybrid hydrogel that is formed from a crosslinkable polymeric micelle and a polyamine. Under optimal conditions, the hydrogel rapidly formed in one second after a crosslinkable polymeric micelle solution was mixed with a polyamine solution. We could change the hydrogel’s gelation properties, such as the storage modulus and gelation time by tuning the molecular weights of block copolymers and by tuning the pH of the dissolving-solvent of the hydrogel’s constituent components. Furthermore, we have clarified here that the structural difference among the micelles acting as crosslinkers can affect the gelation properties of the hydrogel. According to our findings, the hydrogel that was formed from the polymeric micelles possessing a highly packed (i.e., well-entangled or crosslinked) inner core exhibited a higher storage modulus than the hydrogel that was formed from the polymeric micelles possessing a lowly packed structure. Our results demonstrate that a microscopic structural difference among crosslinkers can induce a macroscopic change in the properties of the resulting hydrogels. For medical applications, the hydrogel proposed in the present paper can encapsulate the hydrophobic compounds in crosslinkers (polymeric micelles) so that the hydrogel can be available as the biomaterial for their sustained release.