TITLE:
Unusual Presentation of Endometrial Cancer: A Clinicopathological Study of One Case
AUTHORS:
J. Munné, F. Alameda, A. Bergueiro, G. Mancebo, L. Garrigós, T. Baró, B. Lloveras, J. Gimeno, R. Carreras, S. Serrano
KEYWORDS:
Osseous Metastasis, Endometrial Carcinoma, Immunohistochemistry
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.5 No.1,
January
4,
2015
ABSTRACT: Endometrial carcinoma is the
most frequent genital tract malignancy. The first symptom (guide-symptom) is
usually metrorrhagia; however, in around 10% of cases it is not. In contrast,
osseous metastases are infrequent in endometrial cancer. The bones of the
pelvis and lower extremities are those most frequently involved in disseminated
metastatic diseases. In these cases, endometrial cancer is usually high grade
(Grade III). Case report: 56-year-old woman who presented right inguinal pain.
The X-ray showed a lithic lesion in the right ischium. A histopathological
study demonstrated a metastatic lesion, suspected to be endometrial cancer. The
computer tomography scan revealed a uterine mass and a second lithic lesion in
the right tibia. The patient received chemotherapy (carboplatin and
paclitaxel), and the bone lesions were irradiated. The patient is still alive
18 months after the diagnosis. This case emphasizes the importance of
considering an endometrial primary tumor when evaluating bone metastasis of
unknown primary cancer.