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Mitchell, J.R., Jollow, D.J., Potter, W.Z., Davis, D.C., Gillette, J.R. and Brodie, B.B. (1973) Acetaminophen-Induced Hepatic Necrosis. I. Role of Drug Metabolism. Journal of Pharmacology and Experimental Therapeutics, 187, 185-194.

has been cited by the following article:

• TITLE: A Structure and Antioxidant Activity Study of Paracetamol and Salicylic Acid

  AUTHORS: Rosivaldo S. Borges, Tainá G. Barros, Glaécia A. N. Pereira, João Batista Jr., Raimundo F. G. P. Beleza Filho, Andrex A. S. Veiga, Moisés Hamoy, Vanessa J. Mello, Albérico B. F. da Silva, Carlos A. L. Barros

  KEYWORDS: Paracetamol, Salicylic Acid, Phenol Derivatives, NSAIDs, Antioxidant

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.5 No.13, December 31, 2014

  ABSTRACT: The paracetamol has more antioxidant properties than the salicylic acid on the several oxidative stress-forced models and one possible mechanism is due to electron or hydrogen transfer by the evaluated hydroxyl radicals. The antioxidant mechanism for the compounds studied here was performed by molecular modeling using quantum chemical calculations at the B3LYP level of theory. Our results show that the paracetamol has more antioxidant properties than the salicylic acid in experimental and theoretical studies. The theoretical mechanism show that the hydrogen transfer is more favorable than the electron transfer. From the study it was concluded that the electron abstraction for paracetamol is more favored than salicylic acid.