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Siltari, A., Wickholm, N., Kivimäki, A.S., Olli, K., Salli, K., Tiihonen, K., Korpela, R. and Vapaatalo, H. (2014) Effects of Vitamin K-1 and Menaquinone-7 on Vascular Function and Blood Pressure in Warfarin-Induced Calcification-Model in Rats. Pharmacology & Pharmacy, 5, 1095-1105.
http://dx.doi.org/10.4236/pp.2014.512119

has been cited by the following article:

• TITLE: Possible Correlation between INR and Serum Calcium

  AUTHORS: Tuukka A. Helin, Niko Wickholm, Hannu Kautiainen, Heikki Vapaatalo

  KEYWORDS: Warfarin, INR, Serum Calcium, Vascular Calcification

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.5 No.13, December 26, 2014

  ABSTRACT: Experimental and clinical studies have shown that long term anticoagulation therapy with warfarin can induce vascular calcification which is preventable by vitamin K. Osteoporosis has been shown to be associated with vascular calcification. In the present study, we wanted to see, whether INR (International Normalized Ratio), a measure of prothrombin time, and serum calcium (corrected by albumin) correlate in laboratory data of 94 anticoagulation patients on warfarin therapy. When adjusted on age and sex, there was an inverse correlation between the two variables. Clinical relevance of this observation and explanation of lowered calcium levels in blood parallel to increase in INR-values remain to be studied further.