TITLE:
Levetiracetam-Associated Acute Kidney Injury and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome
AUTHORS:
Mathieu Leblanc, Martin Plaisance
KEYWORDS:
Acute Kidney Injury, DRESS Syndrome, HSV-1, Levetiracetam
JOURNAL NAME:
Open Journal of Nephrology,
Vol.4 No.4,
December
26,
2014
ABSTRACT: DRESS syndrome is a severe drug induced reaction. Acute kidney injury (AKI) is sometimes present in the form of an acute interstitial nephritis. We present the case of a 75-year-old man with glioblastoma who developed a DRESS two months after starting levetiracetam and a few days after stopping dexamethasone. His skin and kidneys improved after removing levetiracetam and introducing again corticosteroids. DRESS has been reported more frequently with other antiepileptics, rarely with levetiracetam. Clinicians should add this drug to the list of potential causes of AKI.