TITLE:
Cytotoxic Activity of Stem Bark Extracts from Canarium odontophyllum Miq (Dabai) against Human Colorectal Carcinoma HCT 116 Cell Line
AUTHORS:
Dayang Fredalina Basri, Muhammad Arifuddin Al Rasyid Mohd, Chan Kok Meng, Elda Surhaida Latif, Fahrul Zaman Huyop
KEYWORDS:
Canarium odontophyllum, Stem Bark, Burseraceae, HCT 116, Cytotoxic Activity, Colorectal Carcinoma
JOURNAL NAME:
American Journal of Plant Sciences,
Vol.5 No.26,
December
24,
2014
ABSTRACT: The preliminary study is aimed at evaluating the cytotoxic activity of crude extracts from the stem bark of Canarium odontophyllum against colorectal carcinoma cell HCT 116. Result of the extraction yield showed that distilled water produced the highest yield (10.58%) followed by methanol (6.55%) whereas acetone extracted the lowest yield (4.58%) from C. odontophyllum stem bark. Phytochemical screening test revealed the presence of terpenoid, flavonoid, tannin, saponin and phenolic compound in all the stem bark extracts of C. odontophyllum. Acetone extract of C. odontophyllum stem bark showed significantly higher (p