TITLE:
Use of MSC in the Treatment of the Congenital Pseudoarthrosis in Children
AUTHORS:
Marina Magnani, Costantina Racano, Caterina Novella Abati, Donatella Granchi, Valentina de Vescovi, Stefano Stilli
KEYWORDS:
Pseudoarthrosis, Mesenchimal Stem Cells, Children
JOURNAL NAME:
Surgical Science,
Vol.5 No.12,
December
24,
2014
ABSTRACT: Congenital
pseudoatrhrosis of the tibia is one of the most frustrating conditions
encountered in paediatric orthopaedic surgery because of the difficulty in
achieving healing; There are different methods of treatment the most commonly
used are: External fixator according Ilizarov’s technique, vascularised fibular
grafting, bone grafting with intramedullary fixation, Boyd’s double bone
grafting and also after several operation go bad and a significant shortening of
the leg even the amputation has to be considered [1] [2]. Numerous treatment
options have been explored with several degree of success. In this paper we
show a combinated surgical technique using autogenous mesenchymal stem cells
(MSC) by precursor of osteogenic differensation at the same time as adjuvant to
the surgical stabilization by an external fixator or an intramedullary nailing.
We used these combined technique in tibia congenital pseudoarthrosis with and
without neurofibromatosis in children. In fact Bone Marrow has been shown to
contain a population of rare mesenchymal stem cells that are capable of forming
bone, cartilage and other connective tissues enhancing bone repair and
regeneration.