TITLE:
11C-Labeling of the C(1)-C(10) Dihydroxy Acid Moiety for the Study on the Synthesis of Kulokekahilide-2 PET Tracer
AUTHORS:
Chunguang Han, Hisashi Doi, Junji Kimura, Yoichi Nakao, Masaaki Suzuki
KEYWORDS:
Kulokekahilide-2, Carbon-11, Boron, C-C Coupling, Isotopic Labeling
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.4 No.4,
December
23,
2014
ABSTRACT: 11C-labeled C1-C10 partial structure of kulokekahilide-2 (1) was successfully synthesized based on Pd0-mediated rapid C-[11C]methylation using [11C]methyl iodide and pinacol alkenylboronate. The preparation of organoboron intermediate via olefin cross-metathesis is also a crucial procedure for the synthesis of 11C-labeling C1-C10 dihy-droxy acid moiety of 1.