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Blount, B.C., Mack, M.M., Wehr, C.M., MacGregor, J.T., Hiatt, R.A., Wang, G., Wickramasinghe, S.N., Everson, R.B. and Ames, B.N. (1997) Folate Deficiency Causes Uracil Mis-incorporation into Human DNA and Chromosome Breakage: Implications for Cancer and Neuronal Damage. Proceedings of the National Academy of Sciences of the USA, 94, 3290-3295. http://dx.doi.org/10.1073/pnas.94.7.3290

has been cited by the following article:

• TITLE: Mathematical Modeling of a Metabolic Network to Study the Impact of Food Contaminants on Genomic Methylation and DNA Instability

  AUTHORS: Etienne Z. Gnimpieba, Souad Bousserouel, Abalo Chango

  KEYWORDS: DNA-Methylation, DNA Instability, Mathematical Modeling, Logic Programming, Metabolic Network, Food Contaminant

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.2 No.10, December 17, 2014

  ABSTRACT: Environmental contamination of food is a worldwide public health problem. Folate mediated one- carbon metabolism plays an important role in epigenetic regulation of gene expression and mutagenesis. Many contaminants in food cause cancer through epigenetic mechanisms and/or DNA instability i.e. default methylation of uracil to thymine, subsequent to the decrease of 5-methylte- trahydrofolate (5 mTHF) pool in the one-carbon metabolism network. Evaluating consequences of an exposure to food contaminants based on systems biology approaches is a promising alternative field of investigation. This report presents a dynamic mathematical modeling for the study of the alteration in the one-carbon metabolism network by environmental factors. It provides a model for predicting “the impact of arbitrary contaminants that can induce the 5 mTHF deficiency. The model allows for a given experimental condition, the analysis of DNA methylation activity and dumping methylation in the de novo pathway of DNA synthesis.