TITLE:
Association between Homa Index and Vascular Endothelial Dysfunction in Type 2 Diabetic Patients
AUTHORS:
N. Rama Kumari, I. Bhaskara Raju, M. Aruna Devi, M. Pallam Praveen
KEYWORDS:
Flow Mediated Dilatation (FMD), Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), Nitroglycerin-Mediated Dilatation (NMD)
JOURNAL NAME:
Open Journal of Internal Medicine,
Vol.4 No.4,
December
15,
2014
ABSTRACT: Introduction: In recent years, flow mediated dilatation (FMD) has become a popular technique in cardiovascular medicine. HOMA-IR was accepted to determine the insulin sensitivity as a valuable standard. In this study, we evaluated the association between HOMA-IR (homeostasis model assessment of insulin resistance) and vascular endothelial dysfunction, as assessed by endothelium- dependent flow-mediated dilatation (FMD) and nitroglycerin-mediated dilatation (NMD), in type 2 Diabetic (DM) patients. Material and Methods: Eighty four (84) consecutive out-patients were enrolled. HOMA-IR was calculated as fasting insulin (μU/ml) multiplied by fasting plasma glucose (FPG) (mg/dl) and divided by 405. The ultrasound method for measuring FMD and NMD has been used. Out of 84 patients, 42 patients were in control group and 42 patients were in diabetic group, which were further subdivided into two groups based on HOMA-IR > 3.0 and above was considered as Group I and HOMA IR