TITLE:
A Review: Interactions of Equine Herpesvirus-1 with Immune System and Equine Lymphocyte
AUTHORS:
Nor Dini Rusli, Khairiyah Binti Mat, Hasnita Che Harun
KEYWORDS:
Equine Herpesvirus-1 (EHV-1), Lymphocyte, Cytotoxic T Lymphocyte (CTL), Immune Response, Peripheral Blood Mononuclear cell (PBMC)
JOURNAL NAME:
Open Journal of Veterinary Medicine,
Vol.4 No.12,
December
12,
2014
ABSTRACT: Equine herpesvirus-1 (EHV-1) remains one of
the most common viral pathogens affecting horses worldwide presenting as a
persistent infection which can establish latency in nerve ganglia (trigeminal
ganglion), lymphoid tissues of the respiratory tract and peripheral blood
lymphocytes. EHV-1 infection induces both humoral and cellular immune responses
in horses. Virus neutralising antibody, particularly in the nasopharynx, is to
kill free virus shed from infected epithelial cells. Hence this antibody has
important functions in reducing virus shedding and spreading infection to
cohorts. Cellular immune responses, particularly those carried out by cytotoxic
T lymphocyte (CTL), have been shown to be effective in killing virus-infected
cells in vitro. This review underlines the state of knowledge regarding
immunity to EHV-1 and also its interaction with equine lymphocyte. Finally, the
review also includes the importance of the viral immediate early (IE) protein
in the pathogenesis of EHV-1. This information can be used as the basis for
future research.