TITLE:
Deterministic Parsing Model of the Compound Biological Effectiveness (CBE) Factor for Intracellular 10Boron Distribution in Boron Neutron Capture Therapy
AUTHORS:
Shintaro Ishiyama
KEYWORDS:
Boron Neutron Capture Therapy, Compound Biological Effectiveness, Borono-Phenyl-Alanine, Tumor, 10B(n, α)7Li
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.14,
December
5,
2014
ABSTRACT: Purpose: In defining the biological effects of the 10B(n, α)7Li neutron
capture reaction, we have previously developed a deterministic parsing model to determine the Compound
Biological Effectiveness (CBE) factor in Borono-Phenyl-Alanine (BPA)-mediated Boron Neutron
Capture Therapy (BNCT). In present paper, we demonstrate that the CBE factor is directly and unambiguously
derivable by the new formula for any case of intracellular 10Boron (10B)
distribution, which is founded on this model for tissues and tumor. Method: To determine the CBE factor,
we derive the following new calculation formula founded on the deterministic
parsing model with three constants, CBE0, F, n and the eigen value Nth/Nmax.
where, Nth and Nmax are the threshold value of boron concentration of N and saturation boron density in
tissues and tumor. In order to determine these constants and the eigen values,
iterative calculation technique was employed for the CEB factor and Nmax data set previously reported. Results and Conclusion: From the iterative calculation
results, it is clear that the calculated CBE factor values obtained are almost
identical to the original CBE factors
and there is a good correlation between the original CBE factors and Nth/Nmax,
when CBE0, F and n are given as 0.5, 8 and 3, respectively. These constants provide a better understanding of different
types of intracellular10B distribution.