Article citationsMore>>

Chopra, I., Hesse, L. and O’neil, L. (2002) Exploiting Current Understanding of Antibiotic Action for Discovery of New Drugs. Journal of Applied Microbiology, 92, 4S-15S.
http://dx.doi.org/10.1046/j.1365-2672.92.5s1.13.x

has been cited by the following article:

• TITLE: Broad Antibacterial Activity of Bothrops jararaca Venom against Bacterial Clinical Isolates

  AUTHORS: Lucas Henrique Cendron, Charise Dallazen Bertol, Daiane Bopp Fuentefria, Elza Maria Calegari, Eliane Dallegrave, Dinara Jaqueline Moura, Kátia Moura, Maria da Graça Marques, Luciana Grazziotin Rossato

  KEYWORDS: Snake Venom, Antibiotic Potential, Toxinology, Bothrops

  JOURNAL NAME: Advances in Microbiology, Vol.4 No.16, December 3, 2014

  ABSTRACT: Purpose: To evaluate the antibacterial activity of Bothrops jararaca venom against bacterial clinical isolates. Methods: Antibacterial activity of Bothrops jararaca venom was evaluated through agar diffusion method against the following bacteria: Acinetobacter baumannii, Oxacillinase-producing Acinetobacter baummanii, extended-spectrum β-lactamase-producing (ESBL) Enterobacter aerogenes, Escherichia coli, Escherichia coli ESBL, Klebsiella pneumoniae, Klebsiella pneumoniae ESBL, Proteus mirabilis, Pseudomonas aeruginosa, metallo β-lactamase-producing Pseudomonas aeruginosa, Staphylococcus aureus, oxacillin resistant Staphylococus aureus (ORSA), Staphylococcus epidermidis, and oxacillin resistant Staphylococus epidermidis.Minimum inhibitory concentration was determined through microdilution plate protocol. Results: The venom presented antibacterial activity against all tested bacteria. More pronounced results were observed to Gram- positive bacteria, especially against ORSA. Conclusion: The present study evidenced the great antibacterial potential of Bothrops jararaca venom showing promising results even with resistant bacterial clinical isolates.