TITLE:
Inhibition of Radiation-Induced Lung Adenocarcinoma Cell Metastasis by Adenovirus of PIAS3 Overexpression Driven by Radiation-Inducible Promoter (Ad-pig3RRP-PIAS3)
AUTHORS:
Ling Gao, Qinghua Yu, Fengsheng Li, Jiangbin Feng, Xue Lu, Qingjie Liu, Xu Su
KEYWORDS:
Radiation, Adenocarcinoma, Metastasis, Promoter, PIAS3
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.14,
December
3,
2014
ABSTRACT: Radiotherapy is one of
important approaches for pulmonary adenocarcinoma. However, many studies have
shown that radiation can also enhance the ability of tumor cells metastasis,
although the lung adenocarcinoma could be killed. The increased metastasis
induced by radiation is associated with the activation of STAT3in lung adenocarcinoma cells.
Based on the importance role ofSTAT3in cell proliferation and
survival, we can construct an adenovirus vector ofPIAS3 overexpress driven by
radiation-induced promoter to inhibit the activation of STAT3
specifically. In this way, whenSTAT3
was activated by radiation, the expression ofPIAS3
will be increased at the same time; this lead to the inhibition of invasion and
metastasis caused bySTAT3
in lung adenocarcinoma cells. These researches are expected to develop a novel
target and method for radiotherapy and molecular therapy of lung adenocarcinoma.