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Ohuchida, K., Mizumoto, K., Murakami, M., Qian, L.-W., Sato, N., Nagai, E., Matsumoto, K., Nakamura, T. and Tanaka, M. (2004) Radiation to Stromal Fibroblasts Increases Invasiveness of Pancrea-Tic Cancer Cells through Tumor-Stromal Interactions. Cancer Research, 64, 3215-3222.
http://dx.doi.org/10.1158/0008-5472.CAN-03-2464

has been cited by the following article:

• TITLE: Inhibition of Radiation-Induced Lung Adenocarcinoma Cell Metastasis by Adenovirus of PIAS3 Overexpression Driven by Radiation-Inducible Promoter (Ad-pig3RRP-PIAS3)

  AUTHORS: Ling Gao, Qinghua Yu, Fengsheng Li, Jiangbin Feng, Xue Lu, Qingjie Liu, Xu Su

  KEYWORDS: Radiation, Adenocarcinoma, Metastasis, Promoter, PIAS3

  JOURNAL NAME: Journal of Cancer Therapy, Vol.5 No.14, December 3, 2014

  ABSTRACT: Radiotherapy is one of important approaches for pulmonary adenocarcinoma. However, many studies have shown that radiation can also enhance the ability of tumor cells metastasis, although the lung adenocarcinoma could be killed. The increased metastasis induced by radiation is associated with the activation of STAT3in lung adenocarcinoma cells. Based on the importance role ofSTAT3in cell proliferation and survival, we can construct an adenovirus vector ofPIAS3 overexpress driven by radiation-induced promoter to inhibit the activation of STAT3 specifically. In this way, whenSTAT3 was activated by radiation, the expression ofPIAS3 will be increased at the same time; this lead to the inhibition of invasion and metastasis caused bySTAT3 in lung adenocarcinoma cells. These researches are expected to develop a novel target and method for radiotherapy and molecular therapy of lung adenocarcinoma.