TITLE:
Fibrolamellar Carcinoma: A Distinct Variant of Hepatocellular Carcinoma That Is Still Surrounded by Unveils Mysteries
AUTHORS:
Consolato Sergi
KEYWORDS:
Liver, Tumor, Carcinoma, Pathogenesis, Differential Diagnosis, Therapy, Prognosis
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.14,
December
3,
2014
ABSTRACT: Fibrolamellar carcinoma
(FL-HCC) is overall a quite rare variant of hepatocellular carcinoma (HCC)that is intriguing and poorly
understood at same time. In humans, it affects essentially the young population
(children and young adults) in the peculiar absence of underlying liver
diseases. FL-HCC has distinctiveclinico-pathologic
features with metastases frequently found in the regional lymph nodes, but also
peritoneum and lungs. Although initially considered harboring an indolent
course, survival outcomes have been recently updated pointing to a neoplasm
concealing many aspects of biogenesis. In this review, morphology, molecular
pathways, and prognosis of this rare tumor are presented.