TITLE:
Paroxetine Increased the Serum Estrogen in Postmenopausal Women with Depressive and Anxiety Symptoms
AUTHORS:
Borong Zhou, Shuangyan Xie, Jiajia Hu, Xiaofang Sun, Haitao Guan, Yanhua Deng
KEYWORDS:
Paroxetine, Estrogen, Anxiety or Depressive Symptom, Cognition, Post-Menopausal Women
JOURNAL NAME:
Open Journal of Depression,
Vol.3 No.5,
November
27,
2014
ABSTRACT: Objective: Both of selective serotonin reuptake inhibitors (SSRIs) and estrogen can modulate emotion and cognition function in post-menopause women, moreover SSRIs can influence estrogen system in rats and aquatic wildlife but most of them for reproductive ability. The aim of this study was to investigate the possible relationship between SSRI, estrogen, and emotion and cognition in post-menopause women with anxiety and depressive symptoms .Methods: A double-blind, randomized controlled trials of Paroxetine, an SSRI (n = 44), versus placebo (n = 38) for 6 months in post-menopausal women with anxiety and depressive symptoms. For screening anxiety, depression and mild cognitive impairment (MCI), we use the Hamilton Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D) and the Chinese Version of the Montreal cognitive assessment (MoCA-CV). And sex hormones were measured by ELASE method which is serum estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH). Results: Paroxetine increased serum E2 and decreased LH, FSH significantly (P