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Chan, C. H., Wills, J., LaCoss, J., Granacki, J. J., and Choma, J., (2007) A novel variable-gain micro-power band-pass auto-zeroing CMOS Amplifier, IEEE Interna- tional Sympo-sium Circuits and Systems, 337–340,.

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• TITLE: Design of low-offset low-power CMOS amplifier for biosensor application

  AUTHORS: Jin-Yong Zhang, Lei Wang, Bin Li

  KEYWORDS: Biomedical Integrated Circuit; CMOS Ampli- fier; Low-Offset and Low-Power; DC Offset Rejection; Bio-medical Sensor

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.2 No.7, November 20, 2009

  ABSTRACT: A compacted and low-offset low-power CMOS am- plifier for biosensor application is presented in this paper. It includes a low offset Op-Amp and a high precision current reference. With a novel continuous-time DC offset rejection scheme, the IC achieves lower offset voltage and lower power consumption compared to previous designs. This configuration rejects large DC offset and drift that exist at the skin-electrode interface without the need of external components. The proposed amplifier has been implemented in SMIC 0.18-μm 1P6M CMOS technol-ogy, with an active silicon area of 100 μm by 120 μm. The back-annotated simulation results demonstrated the circuit features the systematic offset voltage less than 80 μV, the offset drift about 0.27 μV/℃ for temperature ranging from –30℃ to 100℃ and the total power dissipation consumed as low as 37.8 μW from a 1.8 V single supply. It dedicated to monitor low amplitude biomedical signals recording.