TITLE:
Resveratrol—The “Chateau Hormone” for Cardio Diabetic Protection
AUTHORS:
Manish Maladkar, Meenu Awatramani, Kundan Bhong
KEYWORDS:
Resveratrol, Cardiovascular Disease, Atherosclerosis, HDL-C, Diabetes, β-Blockers, Residual Vascular Risk
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.4 No.4,
November
27,
2014
ABSTRACT: Resveratrol is a naturally
occurring phenolic compound abundantly found in grape skin and inwines. Resveratrol is a phytoalexin
trans-3,5,4’-trihydroxystilbene that possesses diverse biochemicaland physiological actions. It is
effective in improving health and preventing or treating chronicdiseases. The
cardiovascular protective effects of Resveratrol suggest the anti-atherogenic
and anti-inflammatory activity of the compound on endothelial cells.
Resveratrol attenuates myocardial ischemic reperfusion injury, atherosclerosis
and reduces ventricular arrhythmias. Resveratrol has been widely studied and is
shown to have anti-oxidant, anti-inflammatory, anti-proliferative andanti-angiogenic effects and many
signalling pathways are among the molecular targets of Resveratrol.Based on these mechanistic
considerations, the involvement of Resveratrol has been observed in
cardiovascular diseases, cancer and neurodegenerative diseases. In type 2
diabetes patients, when Resveratrol was given along with anti-diabetic agents,
it was found to lower blood glucose, HbA1C and increase the insulin sensitivity
and the levels of HDL-C. Resveratrol acts on the SIRT1 gene and stimulates
endogenous pathways to promote health and longevity.