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Ladeira, M.S.P., Bueno, R.C.A., Santos, B.F., Pinto, C.L.S., Prado, R.P., Silveira, M.G., Rodrigues, M.A.M., Bartchewsky, W.J.R., Pedrazzoli, J.J.R., Ribeiro, M.L. and Salvadori, D.M.F. (2008) Relationship among Oxidative DNA Damage, Gastric Mucosal Density and the Relevance of cagA, vacA and iceA Genotypes of Helicobacter pylori. Digestive Diseases and Sciences, 53, 248-255.
http://dx.doi.org/10.1007/s10620-007-9850-0

has been cited by the following article:

• TITLE: Presence of the Genes cagA, cagE, virB11 and Allelic Variation of vacA of Helicobacter pylori Are Associated with the Activity of Gastritis

  AUTHORS: Pedro Pinheiro de Negreiros Bessa, Francivandi Coelho Barbosa, Ana Paula Santos do Carmo, Gildo Barreira Furtado, Fernanda Capelo Barroso, Silvia Helena Barem Rabenhosrt

  KEYWORDS: Active Chronic Gastritis, Inactive Chronic Gastritis, Helicobacter pylori Genotypes

  JOURNAL NAME: Open Journal of Gastroenterology, Vol.4 No.11, November 24, 2014

  ABSTRACT: Non-atrophic active chronic gastritis (ACG) is characterized by the presence of H. pylori in the gastric epithelium, known to be one of the first steps that precede progression to gastric adenocarcinoma. Inactive chronic gastritis (ICG) suggests that the patient has H. pylori gastritis, but this diagnosis is rarely made in routine histopathology. Clinical manifestations associated with H. pylori infection are potentially due to differences in virulence between strains; however, it is unclear if the progression of ACG to ICG depends on the H. pylori strain. The aim of this study was to compare the prevalence of the virulence factors of H. pylori found in patients with ACG and ICG, and its influence on the development of ICG. A significant association was observed between H. pylori detection by histological examination and the activity of gastritis (p 1 year) was reported by 28.6% of the ACG group and 42.5% of the ICG, while no evidence of association between long-term use of PPI and decreased inflammation was found in the patients studied. The genes cagA, cagE and virB11 were statistically associated with ACG (p = 0.01, p vacAs1 allele groups, ACG was associated with the most virulent group (p = 0.0015), while ICG was associated with the less virulent group (p H. pylori in the non-resolution of gastritis.