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Taylor CM, Machin S, Wigmore SJ, Goodship TH. Clinical practice guidelines for the management of atypical haemolytic uraemic syndrome in the United Kingdom. Br J Haematol 2010 Jan; 148(1): 37-47.

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• TITLE: Thrombotic Microangiopathy Induced by Hyperthermal Intraperitoneal Chemotherapy with Mitomycin C

  AUTHORS: Mahir Köksal, Robert J van Ginkel, Jan G Zijlstra

  KEYWORDS: HIPEC, Toxicity, HUS-TTP

  JOURNAL NAME: Surgical Science, Vol.2 No.4, June 23, 2011

  ABSTRACT: A patient with pseudomyxoma peritonei underwent Hyperthermal Intraperitoneal Chemotherapy (HIPEC) with Mitomycin C after which she developed thrombotic microangiopathy. This syndrome mimicked possi-ble surgical complications. Treatment with plasma exchange resolved the syndrome and the patient recov-ered completely. This is the first description of thrombotic microangiopathy early after a single dose intrap-eritoneal Mitomycin C.