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Sennana, S.H., Elghezal, H., Temmi, H., Gribaa, M., Laatiri, A., Ben Abid, H., Ben Abdeladhime, A., Elloumi, M., Hafsia, A. and Saad, A. (2002) Cytogenetic Analysis in 139 Tunisian Patients with de Novo Acute Myeloid Leukemia. Annals of Genetics, 45, 29-32.
http://dx.doi.org/10.1016/S0003-3995(02)01098-5

has been cited by the following article:

• TITLE: New Variant Translocation (8;9;21)(q22;p24;q22) in a Patient with Granulocytic Sarcoma Concurrent with Acute Myeloid Leukemia

  AUTHORS: Gmidène Abir, Wahchi Ines, Meksi Sondes, Jeddi Ramzi, Meddeb Balkis, Saad Ali, Sennana Hlima

  KEYWORDS: Granulocytic Sarcoma, AML-M2, t(8;9;21), Conventional Karyotype, FISH, RUNX1/RUNX1T1

  JOURNAL NAME: Open Journal of Blood Diseases, Vol.4 No.4, November 18, 2014

  ABSTRACT: Granulocytic sarcoma is a form of acute myeloid leukemia which may occur in any anatomical site. Isolated pancreatic granulocytic sarcoma is however, extremely rare. Translocation t(8;21) is the most common cytogenetic abnormality found in leukemia patients with granulocytic sarcoma and is associated with a relatively good prognosis when treated with chemotherapy. Variants of the t(8;21) are uncommon and account for approximately 3% to 4% of acute myeloid leukemia associated with t(8;21) and are rarely described in acute myeloid leukemia cases associated with granulocytic sarcoma. We report here a patient with acute myeloid leukemia and a novel variant t(8;9;21)(q22;p24;q22) with suspected granulocytic sarcoma in pancreas. A dual-color fluorescence in situ hybridization analysis with RUNX1T1 and RUNX1 probes, revealed the presence of an RUNX1/RUNX1T1 fusion signal in this translocation. To the best of our knowledge, a variant of t(8;21) in GS was rarely described and the involvement of the 9q22 region is the first time described here even in isolated AML-M2. We conclude that further accumulation of similar cases is needed and that genetic exploring of variants of t(8;21) may be helpful for a better understanding of molecular pathogenetic mechanism.