TITLE:
Entropy Production Rate for Avascular Tumor Growth
AUTHORS:
Elena Izquierdo-Kulich, Esther Alonso-Becerra, José M Nieto-Villar
KEYWORDS:
Entropy Production Rate, Cancer Robustness, Cancer Evolution
JOURNAL NAME:
Journal of Modern Physics,
Vol.2 No.6A,
June
23,
2011
ABSTRACT: The entropy production rate was determined for avascular tumor growth. The proposed formula relates the fractal dimension of the tumor contour with the quotient between mitosis and apoptosis rate, which can be used to characterize the degree of proliferation of tumor cells. The entropy production rate was determined for fourteen tumor cell lines as a physical function of cancer robustness. The entropy production rate is a hallmark that allows us the possibility of prognosis of tumor proliferation and invasion capacities, key fac-tors to improve cancer therapy.