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H. Kitano, “Cancer as a Robust System: Implications For Anticancer Therapy,” Nature Reviews Cancer, Vol. 4, 2004, pp. 227-235. doi:10.1038/nrc1300

has been cited by the following article:

• TITLE: Entropy Production Rate for Avascular Tumor Growth

  AUTHORS: Elena Izquierdo-Kulich, Esther Alonso-Becerra, José M Nieto-Villar

  KEYWORDS: Entropy Production Rate, Cancer Robustness, Cancer Evolution

  JOURNAL NAME: Journal of Modern Physics, Vol.2 No.6A, June 23, 2011

  ABSTRACT: The entropy production rate was determined for avascular tumor growth. The proposed formula relates the fractal dimension of the tumor contour with the quotient between mitosis and apoptosis rate, which can be used to characterize the degree of proliferation of tumor cells. The entropy production rate was determined for fourteen tumor cell lines as a physical function of cancer robustness. The entropy production rate is a hallmark that allows us the possibility of prognosis of tumor proliferation and invasion capacities, key fac-tors to improve cancer therapy.