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Provenzano, P.P., Rueden, C.T., Trier, S.M., Yan, L., Ponik, S.M., Inman, D.R., Keely, P.J. and Eliceiri, K.W. (2008) Nonlinear Optical Imaging and Spectral-Lifetime Computational Analysis of Endogenous and Exogenous Fluorophores in Breast Cancer. Journal of Biomedical Optics, 13, Article ID: 031220. http://dx.doi.org/10.1117/1.2940365

has been cited by the following article:

• TITLE: Colon Adenocarcinoma Diagnosis in Human Samples by Multicontrast Nonlinear Optical Microscopy of Hematoxylin and Eosin Stained Histological Sections

  AUTHORS: Javier Adur, Mariana Bianchi, Vitor B. Pelegati, Silvia Viale, María F. Izaguirre, Hernandes F. Carvalho, Carlos L. Cesar, Víctor H. Casco

  KEYWORDS: Nonlinear Microscopy, Nonlinear Multicontrast, Histological Sections, Human Colon Cancer

  JOURNAL NAME: Journal of Cancer Therapy, Vol.5 No.13, November 17, 2014

  ABSTRACT: Combined multimodal nonlinear optical (NLO) microscopies were used to detect and quantify morphological changes associated with stroma and epithelial transformation in colon cancer. Our findings provide complementary information about tissue microstructure, displaying distinctive patterns between normal and malignant human colon. Additionally, we have demonstrated the usefulness of using fixed tissues for the disease diagnostic and prognostic.The present work provides a framework for using NLO techniques as a clinical diagnostic tool for human colon cancer. NLO metrics could be applied to other disorders, which are characterized by abnormal cell proliferation and collagen assembly.