TITLE:
Effect of Citrus aurantium L. Essential Oil and Haloperidol on Anxiety in Male Mice
AUTHORS:
Shahrzad Khakpour, Maryam Khosravi, Zahra Mashayekhipour, Mahsa Hadipour Jahromy
KEYWORDS:
Anxiety, Citrus aurantium L., Essential Oil, Haloperidol, Mice
JOURNAL NAME:
World Journal of Neuroscience,
Vol.4 No.5,
November
11,
2014
ABSTRACT: Relationship between sociability and the amount of brain’s dopamine is very well known. In this study, we have examined the effect of Citrus aurantium L. essential oil on anxiety and its interaction with dopaminergic pathways. 70 male mice were assigned into experimental, control, and sham groups. Essential oil of Citrus aurantium L. was injected intraperitonealy at doses of 0.5%, 2.5% and 5% for 5 days. Subcutaneous injection of haloperidol was administered on the fifth day, 30 minutes before the injection of the essential oil. The anxiety-related behavior of mice was then assessed by elevated plus-maze test. The result of this study showed that the injection of Citrus aurantium L. essential oil at doses of 2.5% and 5% increased significantly the time spent in the open arms (OAT) (p