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Niu, G., Wright, K.L., Huang, M., Song, L., Haura, E., Turkson, J., Zhang, S., Wang, T., Sinibaldi, D., Loppola, D., Heller, R., Ellis, L.M., Karras, J., Bromberg, J., Pardoll, D., Jove, R. and Yu, H. (2002) Constitutive Stat3 Activity Up-Regulates VEGF Expression and Tumor Angiogenesis. Oncogene, 21, 2000-2008. http://dx.doi.org/10.1038/sj.onc.1205260

has been cited by the following article:

• TITLE: Protein Expression of STAT3, pSTAT3, MMP-7 and VEGF in Colorectal Adenocarcinoma: An Immunohistochemical Study

  AUTHORS: Rakesh Naidu, Lim Vin Nee, Mak Joon Wah, Kevin Moissinac, A. Rahman A. Jamal, Isa Mohd Rose, Yunus Gul Alif Gul, Patricia Lim Kim Chooi, Gregory Tan Jin San

  KEYWORDS: STAT3, pSTAT3, MMP-7, VEGF, Colorectal Adenocarcinoma

  JOURNAL NAME: Journal of Cancer Therapy, Vol.5 No.13, November 7, 2014

  ABSTRACT: Background: The purpose of the present study is to investigate the expression levels of STAT3, pSTAT3, MMP-7 and VEGF in colorectal adenocarcinoma, and also to determine association with the clinico-pathological parameters andco-expression of these genes. Methods: An immunohistochemical method was used to evaluate the expression of MMP-7 and VEGF genes in 93 archival tissues whereas STAT3 and pSTAT3 expression was determined in 75 cases. Results: Overexpression of STAT3 was detected in 26.7% (20/75), pSTAT3 in 13.4% (10/75), MMP-7 in 38.8% (36/93) and VEGF in 59.2% (55/93) of the colorectal carcinomas. STAT3, MMP-7 and VEGF immunopositivity were significantly correlated with poorly-differentiated tumors (P = 0.004; P = 0.03; P = 0.002, respectively) but not with other parameters. However, pSTAT3 immunostaining was not significantly associated with the clinico-pathological characteristics. Significant relationship was noted between overexpression of pSTAT3 and STAT3 (P Our data suggest that expression of these genesmay have an important role in tumor dedifferentiation andmay be useful as indicators of biologic aggressiveness. Co-expression of the biomarkers by cancer cellsmay have important implications in colorectal cancer biology andcould be useful biological markers of the malignant phenotype.