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Joshipura, K.J., Hu, F.B., Manson, J.E., Stampfer, M.J., Rimm, E.B., Speizer, F.E., Colditz, G., Ascherio, A., Rosner, B., Spiegelman, D. and Willett W.C. (2001) The effect of fruit and vegetable intake on risk for coronary heart disease. Annals of Internal Medicine, 134, 1106 -1114.

has been cited by the following article:

• TITLE: The antithrombotic effects of onion filtrates in rats and mice

  AUTHORS: Kanae Hyodo, Izumi Horii, Masaru Nishino, John C Giddings, Junichiro Yamamoto

  KEYWORDS: Cardiovascular Disease; Stroke; Atherothrombosis; Onion; Quercetin

  JOURNAL NAME: Health, Vol.3 No.6, June 21, 2011

  ABSTRACT: The prevention of arterial thrombotic disease has a high priority in developed countries. An inappropriate diet is known to enhance the risk for acute thrombotic events, and a regular diet with proven antithrombotic effects might be a beneficial way to prevent disease. The present study was undertaken as part of a series of in-vestigations to examine various vegetables and fruits for antithrombotic activity, and to add to the previously reported data on different onion varieties produced in the northern part of Japan (Hokkaido). For this purpose, a sophisticated method to assess shear-induced platelet reac-tivity/thrombolysis in vitro (The Global Throm-bosis Test, GTT) was used to screen 5 different varieties of onion produced in the middle part of Japan (Awaji Island). The different onion varie-ties demonstrated a variable effect on thrombo-sis, and one particular variety, designated ONA-03, appeared to exert an antithrombotic effect. Another variety, ONA-01, appeared to have prothrombotic activity by inhibiting spon-taneous thrombolytic activity. The especially effective variety was further investigated using an in vivo, laser-induced thrombosis model in mice. The heat stable antithrombotic activity in vitro and in vivo was demonstrated to be due to antiplatelet activity. The present findings added to the list of antithrombotic fruits and vegeta-bles.