TITLE:
Effectiveness of Bemiparin Sodium for Preventing Pregnancy Loss in Patients with MTHFR C677T Mutation and Habitual Abortus
AUTHORS:
Davut Guven, Kadir Bakay, Idris Kocak, Ayse Ozdemir
KEYWORDS:
Habitual, Abortion, MTHFR, Bemiparin, LMWH
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.4 No.15,
November
5,
2014
ABSTRACT: Objective: In this study the purpose is to
evaluate the effectiveness of daily bemiparin sodium injection in preventing
early pregnancy loss and in achieving live births in pregnant patients, not
ahead of 6th week, who are diagnosed with habitual abortion in a
case-controlled randomized prospective study. Study Design: In this prospective
study, 120 pregnant patients not ahead of 6th week and aged between 21 - 36 and
diagnosed with habitual abortion between April 2011 and April 2012 in our
clinic were included. Habitual abortion diagnosis criteria was based on patient
history of three or more miscarriages before the 20th week and a genetically
documented homozygote or heterozygote mutation of the methylenetetrahydrofolate
Reductase gene. Results: The rate and the number of live births in the study
group was 60 (93.75%) and statistically higher than the control group 32
(57.14%). The difference was found to be statistically significant (p = 0.001).
The rate and the number of abortions in the control group was 24 (42.85%) and
statistically higher than the study group 4 (6.25%). The difference was found
to be statistically significant (p = 0.001). Conclusion: In order to maintain a
healthy pregnancy an effective uteroplacental circulation is a must and any
defects in haemostasis mechanisms may have an adverse influence. A few
non-randomized studies comparing pregnancy results of low dose salycilic acid
and low molecular weight heparin usage in patients also show that prophylaxis
might be beneficial.