TITLE:
Pregnancy with Gastric Stromal Tumor
AUTHORS:
Iliass Charif, Najat Khalil, Abdelmalek Ousadden, El Bachir Benjelloun, Ouafae Slimani, Fatima Zahra Fdili Alaoui, Fatima Zahra Hijri, Omar Mesbahi, Adil Ibrahimi, Ihsane Mellouki
KEYWORDS:
GIST, Pregnancy, Imatinib
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.3 No.11,
November
4,
2014
ABSTRACT: Background: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. GIST are rare during pregnancy. We report here the case of a patient who was admitted in our university hospital for GIST discovered during the second trimester of pregnancy. She was 42 years old, in the fifth months of pregnancy. She was admitted for biliary colic pain with vomiting. On abdominal examination, we objectified a distended abdomen with uterine height of 18 cm and epigastric mass of 10 cm. Abdominal ultrasound and magnetic resonance imaging (MRI) showed a hepatic, tissue and cystic mass, developing at the expense of the left liver. Endoscopy objectified an aspect of extrinsic compression at the front of the stomach. A cesarean was scheduled at the 35th month of pregnancy for fetal extraction and rescue. Exploration of the peritoneal cavity during surgery has objectified a hepatic highly vascularised mass reaching up to the umbilicus. This mass was unresectable. A postoperative CT scan revealed a large bilobed epigastric mass adhering to the stomach and the left liver. Histological and immunohistochemical study of hepatic process showed a gastrointestinal stromal tumor of high risk of malignancy. Conclusion: few cases have been reported in the literature on GIST during pregnancy showing the rarity of the condition that requires multidisciplinary care.