TITLE:
A Study of the Effect of Citrus aurantium L. Essential Oil on Anxiety and Its Interaction with GABAergic Pathways in Male Mice
AUTHORS:
Maryam Khosravi, Shahrzad Khakpour, Leila Adibi, Mahsa Hadipour Jahromy
KEYWORDS:
Anxiety, Mice, Citrus aurantium L., Diazepam
JOURNAL NAME:
Journal of Behavioral and Brain Science,
Vol.4 No.10,
October
28,
2014
ABSTRACT: Anxiety is among
the most common disorders affecting a great number of people. Different neurotransmitter
systems, such as GABAergic system, play an important role in emergence of
anxiety-related behaviors. In this study, we have investigated the effect of Citrus
aurantium L. essential oil on anxiety and its interaction with GABAergic
pathways. Male mice were assigned into control, sham, and experimental groups.
Intraperitoneal injection of Citrus aurantium L. essential oil
was applied at doses of 0.5, 2.5, and 5 percent for 5 days. Diazepam (0.1 mg/kg)
was injected on the fifth day, thirty minutes before applying Citrus aurantium L. essential oil. The anxiety-related behavior of mice was then
assessed using elevated plus-maze test. In groups receiving Citrus aurantium L. essential oil at doses of 2.5 and 5 percent, the percent time
spent in the open arms increased significantly (P Citrus aurantium L. essential oil resulted in increasing in the number of entries to
the open arms and the percent time spent in the open arms (P Citrus aurantium L. essential oil can reduce anxiety-related behaviors in male mice thah may act
via GABAergic system.