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Krekel, N.M., Haloua, M.H., Cardozo, A.M.L., de Wit, R.H., Bosch, A.M., de Widt-Levert, L.M., et al. (2013) Intraoperative Ultrasound Guidance for Palpable Breast Cancer Excision (COBALT Trial): A Multicentre, Randomised Controlled Trial. The Lancet Oncology, 14, 48-54.
http://dx.doi.org/10.1016/S1470-2045(12)70527-2

has been cited by the following article:

• TITLE: The Centricity Score: A Novel Measurement to Aid in Conservative Breast Cancer Surgery

  AUTHORS: Ryan Sugrue, Katherine McGowan, Cillian McNamara, Michael Sugrue

  KEYWORDS: Breast Cancer, Wide Local Excision, Positive Margins, Re-Excision Rates, Specimen Radiography

  JOURNAL NAME: Advances in Breast Cancer Research, Vol.3 No.4, October 22, 2014

  ABSTRACT: Introduction: This study describes an intra-operative scoring system to advise the surgeon of thecentricity of the tumour in the excised specimen. Methods: Spatial estimations were prospectively made in 10 consecutive patients undergoing wide local excision (WLE) using Bioptics intra-operative digital specimen imaging. The centricity score was defined as 100 – (ICD/SD×100), where ICD is the inter-centre distance between the specimen’s centre and the tumour’s centre. Results: 10 patients with invasive breast cancer (T1b to T4a), mean age 56 years (range 44 - 71) were studied. The mean tumour and specimen diameter was 24 mm ± 10 (range 12 - 48) and 101 mm ± 22 (range 64 - 140). The mean centricity score was 86 ± 9 (range 65 - 95). Conclusion:This study successfullydescribes an intraoperative radiological spatial scoring system for patients undergoing WLE. Tumours were well centered in specimens with an overall score of 86/100. The centricity score couldbe used to guide excision and potentially set benchmarks for conservative breast surgery.