TITLE:
The Effect of Oral Melissa officinalis on Serum Oxidative Stress and Second Degree Burn Wounds Healing
AUTHORS:
Masumeh Abbasdust Arbastan, Kobra Rahzani, Davood Hekmatpou, Shaban Ali Alizadeh, Mohammad Rafiei, Ali Akbar Malekirad
KEYWORDS:
Burn Wounds Healing, Lemon Balm, Oxidative Stress
JOURNAL NAME:
Health,
Vol.6 No.18,
October
20,
2014
ABSTRACT: For this aim, this
study conducted in order to assess the effect of lemon balm as an antioxidant
on second degree wound healing and
oxidative stress serum of burning patients. To meet the aim, 60 patients with
15 to 50 burn percent with the age range of 18 to 50 were invited after
considering to inclusion criteria by the researchers. First they have been put
by non-probable method and then random method in two groups of experiment (30
people) and control (30 people). After that,
experiment group in addition to ordinary treatment has been used Melissa
officinalis (lemon balm) plant two times a day for two weeks (1.5 g
in 100 cc). Oxidative stress parameters included serum total antioxidant and
the rate of malondialdehyde (MDA) that is one of total production of lipid
peroxidation have been measured in patients’ blood sample in first and last
parts of the study. The wound position
has been studied by using standard wound BATES-JENSEN assessment tool in first,
seventh and fifteenth days of study. In order to analyze data, independent
sample t-test, paired sample t-test and repeated measurement variance have been
used. These results indicated that the state of wound healing in experimental
group was better than that in control group. Results indicated that mean of
serum total antioxidant had been increased in both groups. The index of lipid
peroxidation at the end of period has been increased in experiment group than
control group, whether this index is significantly decreased at the end of 15
days in experimental group. According to the results of this study, the effect
of Melissa officinalis (lemon balm) plant was effective in increasing
lipid peroxideative in better states of second degree burn wound healing.