TITLE:
Multicenter Survey of the Isometric Lower Extremity Strength in Patients with Type 2 Diabetes (MUSCLE-std): Design and Study Protocol
AUTHORS:
Takuo Nomura, Tomoyasu Ishiguro, Masayoshi Ohira, Yukio Ikeda, Masahito Watanabe
KEYWORDS:
Muscle Strength, Knee Joint, Diabetes Mellitus, Diabetic Neuropathies, Physical Therapy
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.4 No.4,
October
16,
2014
ABSTRACT: Background: The lower
extremity muscle strength has been shown to be weaker in patients with diabetes
mellitus, primarily due to the effects of diabetic polyneuropathy, a common
diabetic complication. With respect to assessments of the lower extremity
muscle strength, reference values for the knee extension force in healthy
Japanese subjects have been reported. The clinical significance of applying
knee extension force in the assessment of efficacy of exercise therapy and patient
education has also been demonstrated, and the use of an individualized approach
in physical exercise based on the quantitative assessment of the lower
extremity muscle strength is becoming one of the most important strategies for
promoting effective rehabilitation. Methods: The study is a multicenter,
cross-sectional investigation. We will measure the knee extension force and evaluate
the diabetic polyneuropathy in patients with type 2 diabetes using uniform
equipment and methodology at all centers. We will compare the knee extension
force between the subjects with and without diabetic polyneuropathy and will
investigate the associations between the knee extension force and both glycemic
control and exercise habits. The trial registration is UMIN CTR
(UMIN000002810). Discussion: The lower extremity muscle strength has been
insufficiently investigated in Japanese patients with diabetes. This study was
designed to establish reference values for the knee extension force in Japanese
diabetic patients with and without diabetic polyneuropathy.