TITLE:
Antiobesity Activity of Bauhinia purpurea Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats
AUTHORS:
Tiruttani Kuppireddy Padmaja, Parim Brahma Naidu, Ghali Eswara Naga Hanuma Kumar, Saravanan Ganapathy, Meriga Balaji
KEYWORDS:
Obesity, Leptin, Fat Free Mass, Dyslipidemia, Inslin Resistance
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.5 No.11,
October
14,
2014
ABSTRACT: Obesity is well
recognized as a global public health concern and the quest continues to explore
natural product-based novel therapeutics. Bauhinia
purpurea finds its place in traditional medicine as an effective
anti-ulcer, antiplatelet, wound healing and hypolipidemic agent. The present
study investigated the effects of ethanolic extract of Bauhinia purpurea (EEB) on the changes in body weight, lean mass,
fat free mass, fat percent, tissue and plasma lipid profiles, plasma glucose,
insulin and insulin resistance as well as on the activity of amylase, lipase,
leptin and adiponectin levels in high caloric diet (HCD) induced obese rats.
After induction of obesity with HCD, rats were administered orally with EEB
(100, 200 and 300 mg·kg-1 BW) or orlistat (5 mg·kg-1 BW)
once daily for 42 days. HCD substantially increased the body weight, fat free
mass, fat percent, glucose, insulin resistance, tissue and plasma lipid
profiles (Except HDL), leptin and the activities of amylase and lipase. EEB at
a dose of 300 mg·kg-1 BW exerted its therapeutic effects similar to
orlistat in decreasing body weight, insulin resistance, levels of glucose,
leptin, plasma and tissue lipids, lipase and amylase but increasing HDL and
adiponectin in HCD fed obese rats, which could be due to bioactive factors
present in EEB, as revealed by LC-MS analysis. These findings suggest that EEB
administration suppresses high-caloric-diet-induced obesity and it can be
developed as a potential candidate for the treatment of obesity and associated
complications.