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[10] B. J. Materson, D. J. Reda, W. C. Cushman, B. M. Massie, E. D. Freis, M. S. Kochar, R. J. Hamburger, C. Fye, R. Lakshman, J. Gottdiener, E. A. Ramirez and G. Willium, “Single-Drug Therapy for Hypertension in Men. A Com-parison of Six Antihypertensive Agents with Placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents,” The New England Journal of Medicine, Vol. 328, No. 13, 1993, pp. 914-921. doi:10.1016/j.ehj.2004.07.025

has been cited by the following article:

• TITLE: Efficacy and Tolerability of Candesartan Cilexetil and Amlodipine in Patients with Poorly Controlled Essential Hypertension

  AUTHORS: Kazuaki Nishio, Takeshi Kondo, Youichi Kobayashi

  KEYWORDS: Amlodipine, Candesartan, Combined Therapy, Hypertension

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.2 No.2, May 27, 2011

  ABSTRACT: Current treatment guidelines for hypertension in both Europe and the USA stress the importance of aggressive blood pressure control. When monotherapy is not enough to reach treatment targets, there is a need for combination regi-mens that have both high efficacy and good tolerability. The aim of this study is to evaluate the efficacy and toler-ability of the combination therapy candesartan and amlodipine in patients with hypertension not satisfactorily controlled by monotherapy. Patients with uncomplicated essential hypertension not satisfactorily controlled by monotherapy, which is candesartan 8 mg or amlodipine 5 mg, were eligible. Candesartan 8 mg and amlodipine 5 mg were given for 12 weeks. 13 patients who received candesartan 8 mg previoursly were assigned to the candesartan group and 8 patients who received amlodipine 5 mg previoursly were assigned to the amlodipine group. Sitting systolic blood pressure (SBP) at baseline was 151.9 ± 11.6 mmHg in the candesartan group, and 154.6 ± 7.6 mmHg in the amlodipine group. Sitting diastolic blood pressure (DBP) was 93.2 ± 13.1 in the candesartan group, and 80.4 ± 14.7 in the amlodipine group. DBP in the amlodipine group was lower than that in the cadesartan group (P = 0.036). After the combination therapy, SBP was significantly reduced in the two groups. DBP showed significant reduction in the amlodipine group. The rate of achieving blood pressure goals was 4% at baseline and significantly increased to 58% after the combination therapy. These results showed that candesartan 8 mg/amlodipine 5 mg are effective lowering blood pressure after 12 weeks in patients not adequately controlled by monotherapy.