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Zhu, B., Jaffer, F.A., Ntziachristos, V. and Weissleder, R. (2005) Development of a Near Infrared Fluorescence Catheter: Operating Characteristics and Feasibility for Atherosclerotic Plaque Detection. Journal of Physics D, 38, 2701-2707.

has been cited by the following article:

• TITLE: Observation of Atherosclerotic Plaque Phantoms through Saline or Blood Layers by Near-Infrared Hyperspectral Imaging

  AUTHORS: Katsunori Ishii, Akiko Kitayabu, Ryo Nagao, Kunio Awazu

  KEYWORDS: Hyperspectral Imaging, Near-Infrared Range, Atherosclerotic Plaque, Angioscopy

  JOURNAL NAME: Optics and Photonics Journal, Vol.4 No.10, October 13, 2014

  ABSTRACT: We observed atherosclerotic plaque phantoms using a novel near-infrared (NIR) hyperspectral imaging (HSI) technique. Data were obtained through saline or blood layers to simulate an angioscopic environment for the phantom. For the study, we developed a NIR-HSI system with an NIR supercontinuum light source and mercury-cadmium-telluride camera. Apparent spectral absorbance was obtained at wavelengths of 1150 - 2400 nm. Hyperspectral images of lipid were constructed using a spectral angle mapper algorithm. Bovine fat covered with saline or blood was observed using hyperspectral images at a wavelength around 1200 nm. Our results show that NIR-HSI is a promising angioscopic technique with the potential to identify lipid-rich plaques without clamping and saline injection.