TITLE:
Escherichia coli Population-Based Study in Pediatric Crohn’s Disease
AUTHORS:
Serena Schippa, Valentina Totino, Massimiliano Marazzato, Maria Stefania Lepanto, Floriana Santangelo, Marta Aleandri, Antonella Gagliardi, Catia Longhi, Fabrizio Pantanella, Valerio Iebba, Maria Pia Conte
KEYWORDS:
Escherichia coli, Mucosa-Associated, Crohn’s Disease
JOURNAL NAME:
Advances in Microbiology,
Vol.4 No.13,
October
9,
2014
ABSTRACT: Escherichia coli is assumed to be
involved in inflammatory bowel disease (IBD) by many authors. The present Short
Report was aimed at analyzing E. coli population isolated from ileal samples collected from 4 CD and 3 non-CD
(control group) diagnosed pediatric patients. A total of 539 mucosa-associated E. coli strains were characterized by: Random Amplified Polymorphic
DNA (RAPD), adhesive and virulence factors, and for their phylogenetic
groups. A significant separation between
RAPD profiles of the two CD and non-CD cohorts (P duction of intra-species genomic variability in E. coli populations isolated from CD
group (P E. coli populations (K1, IbeA)
(P E. coli population,
particular variants may be favorite in the intestinal habitat of CD pediatric
patients. These genotype variants could represent the genetic background that,
via evolutionary phenomena driven by a persistent inflammatory state, may
evolve in Adherent Invasive Escherichia
coli (AIEC) like strains found in adult CD patients.