TITLE:
Enhanced stability of nano-emulsified paclitaxel
AUTHORS:
Ju Young Lee, Da Yeon Kim, Gyeong Hae Kim, Kkot Nim Kang, Byoung Hyun Min, Bong Lee, Jae Ho Kim, Moon Suk Kim
KEYWORDS:
Self-Microemulsifying; Paclitaxel; Stability; Anti-Tumor Activity
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.4 No.5,
May
17,
2011
ABSTRACT: The main goal of this work was to develop an optimal self-microemulsifying paclitaxel prepared with PLGA and solubilizer such as tetraglycol, Cremophor ELP, and Labrasol. The prepared PTx-loaded SMES showed the size of the range of 80–130 nm by dy-namic light scattering and a spherical shape by atomic force microscopy. In experiment of storage stability in deionized water (DW) or blood condition, PTx-loaded SMES showed good stability in DW and comparable stability in blood condition at 37oC for 7 days. In addition, PTx-loaded SMES showed a sig-nificant inhibitory effect on B16F10 melanoma proli-feration. In conclusion, we confirmed that the for-mulations tried in this study could be used as admin-istration form for animal trials of PTx.